Epigenetics :
Epigenetics : mechanisms and clinical perspectives /
Yildiz Dincer, editor.
- 1 online resource.
- Genetics - research and issues .
- Genetics--research and issues series. .
Includes index.
Includes bibliographical references and index.
EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; CONTENTS; PREFACE ; Chapter 1 EPIGENETIC MODIFICATIONS AND DEVELOPMENTAL ORIGIN OF HEALTH AND DISEASES (DOHAD) ; Abstract; Abbreviations; 1. Introduction; 2. What Is Epigenetics?; 2.1. DNA Methylation; 2.2. MicroRNAs; 3. Evidence from Human Cohorts; 3.1. Fetal Programming Hypothesis; 3.2. DNA Methylation and Fetal Programming Hypothesis; 3.3. MicroRNAs and Fetal Programming Hypothesis; 4. Evidence from Animal Experiments; 4.1. DNA Methylation and Animal Experiments 4.1.1. Maternal Nutrition4.1.2. Paternal Nutrition; 4.2. MicroRNAs and Animal Experiments; 4.2.1. Maternal Nutrition; 4.2.2. Paternal Nutrition; 5. Developmental Plasticity and Reversibility; Conclusion and Further Perspective; References; Chapter 2 EFFECTS OF OXIDATIVE STRESS ON EPIGENETIC MECHANISMS ; Abstract; Abbreviations; 1. Epigenetic Mechanisms; 1.1. DNA Methylation; 1.2. Histone Post-translational Modifications; 1.3. Micro RNAs and Epigenetic; 2. Oxidative Stress; 3. Interactions between Oxidative Stress and Epigenetic Mechanisms; 3.1. Oxidative Stress -- DNA Methylation 3.2. Oxidative Stress -- Histone Post-Translational Modifications3.3. Oxidative Stress -- miRNAs; Conclusion; References; Chapter 3 EPIGENETIC MODIFICATIONS AND THEIR POTENTIAL ROLE IN TUMORIGENESIS ; Abstract; Abbreviations; 1. Introduction; 2. The Dysregulation of Epigenetic Factors in Various Cancers; 2.1. The Deregulation of DNA Methylation in Cancer; 2.2. The Deregulation of Histone Lysine Methylation in Cancer; 2.3. The Deregulation of Histone Lysine Demethylases in Cancer; 3. Histone Lysine Acetylation in Cancer 3.1. The Deregulation of Histone Lysine Acetyltransferases in Tumor Proliferation and Metastasis3.2. The Deregulation of Histone Lysine Deacetylases (KDACs) in Cancer; 4. Histone Acetylation "Code" as a Diagnostic Marker for Cancer Progression; 5. Epigenetic Modifications in Oncogenes and Tumor Suppressor Genes; 6. Epigenetic Modifications in Cellular Signaling Pathways; 6.1. NF-(B Signaling Pathway; 6.2. STAT3 Signaling Cascade; 6.3. Wnt/(-Catenin Signaling Pathway; 7. Epigenetic Modification in Cancer Stem Cells
9781634845199 1634845196
2016000949
Epigenetics.
Genetic regulation.
Epigenomics.
SCIENCE--Life Sciences--Biochemistry.
Epigenetics.
Genetic regulation.
Electronic books.
QH450
572.8/65
QU 475
Includes index.
Includes bibliographical references and index.
EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; CONTENTS; PREFACE ; Chapter 1 EPIGENETIC MODIFICATIONS AND DEVELOPMENTAL ORIGIN OF HEALTH AND DISEASES (DOHAD) ; Abstract; Abbreviations; 1. Introduction; 2. What Is Epigenetics?; 2.1. DNA Methylation; 2.2. MicroRNAs; 3. Evidence from Human Cohorts; 3.1. Fetal Programming Hypothesis; 3.2. DNA Methylation and Fetal Programming Hypothesis; 3.3. MicroRNAs and Fetal Programming Hypothesis; 4. Evidence from Animal Experiments; 4.1. DNA Methylation and Animal Experiments 4.1.1. Maternal Nutrition4.1.2. Paternal Nutrition; 4.2. MicroRNAs and Animal Experiments; 4.2.1. Maternal Nutrition; 4.2.2. Paternal Nutrition; 5. Developmental Plasticity and Reversibility; Conclusion and Further Perspective; References; Chapter 2 EFFECTS OF OXIDATIVE STRESS ON EPIGENETIC MECHANISMS ; Abstract; Abbreviations; 1. Epigenetic Mechanisms; 1.1. DNA Methylation; 1.2. Histone Post-translational Modifications; 1.3. Micro RNAs and Epigenetic; 2. Oxidative Stress; 3. Interactions between Oxidative Stress and Epigenetic Mechanisms; 3.1. Oxidative Stress -- DNA Methylation 3.2. Oxidative Stress -- Histone Post-Translational Modifications3.3. Oxidative Stress -- miRNAs; Conclusion; References; Chapter 3 EPIGENETIC MODIFICATIONS AND THEIR POTENTIAL ROLE IN TUMORIGENESIS ; Abstract; Abbreviations; 1. Introduction; 2. The Dysregulation of Epigenetic Factors in Various Cancers; 2.1. The Deregulation of DNA Methylation in Cancer; 2.2. The Deregulation of Histone Lysine Methylation in Cancer; 2.3. The Deregulation of Histone Lysine Demethylases in Cancer; 3. Histone Lysine Acetylation in Cancer 3.1. The Deregulation of Histone Lysine Acetyltransferases in Tumor Proliferation and Metastasis3.2. The Deregulation of Histone Lysine Deacetylases (KDACs) in Cancer; 4. Histone Acetylation "Code" as a Diagnostic Marker for Cancer Progression; 5. Epigenetic Modifications in Oncogenes and Tumor Suppressor Genes; 6. Epigenetic Modifications in Cellular Signaling Pathways; 6.1. NF-(B Signaling Pathway; 6.2. STAT3 Signaling Cascade; 6.3. Wnt/(-Catenin Signaling Pathway; 7. Epigenetic Modification in Cancer Stem Cells
9781634845199 1634845196
2016000949
Epigenetics.
Genetic regulation.
Epigenomics.
SCIENCE--Life Sciences--Biochemistry.
Epigenetics.
Genetic regulation.
Electronic books.
QH450
572.8/65
QU 475