000			04798cam a2200661 i 4500
001			ocn934383097
003			OCoLC
005			20200827111348.0
006			m o d
007			cr |||||||||||
008			160108s2016 nyu o 001 0 eng
010			_a 2016000949
040			_aDLC _beng _erda _cDLC _dOCLCF _dN$T _dEBLCP _dNRC _dYDX _dSNK _dDKU _dAUW _dIGB _dD6H _dVTS _dAGLDB _dG3B _dS8J _dS9I _dSTF _dM8D _dDLC _dOCLCO _dAU@ _dVLY
019			_a960444054 _a1043351382
020			_a9781634845199 _q(ebook)
020			_a1634845196
020			_z9781634844901 _q(hardcover)
020			_z1634844904
029	1		_aAU@ _b000062420260
035			_a(OCoLC)934383097 _z(OCoLC)960444054 _z(OCoLC)1043351382
042			_apcc
050	1	0	_aQH450
060		4	_aQU 475
072		7	_aSCI _x007000 _2bisacsh
082	0	0	_a572.8/65 _223
049			_aMAIN
245	0	0	_aEpigenetics : _bmechanisms and clinical perspectives / _cYildiz Dincer, editor.
264		1	_aNew York : _bNova Biomedical, _c[2016]
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
490	1		_aGenetics - research and issues
500			_aIncludes index.
588			_aDescription based on print version record and CIP data provided by publisher.
504			_aIncludes bibliographical references and index.
505	0		_aEPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; EPIGENETICS MECHANISMS AND CLINICAL PERSPECTIVES; CONTENTS; PREFACE ; Chapter 1 EPIGENETIC MODIFICATIONS AND DEVELOPMENTAL ORIGIN OF HEALTH AND DISEASES (DOHAD) ; Abstract; Abbreviations; 1. Introduction; 2. What Is Epigenetics?; 2.1. DNA Methylation; 2.2. MicroRNAs; 3. Evidence from Human Cohorts; 3.1. Fetal Programming Hypothesis; 3.2. DNA Methylation and Fetal Programming Hypothesis; 3.3. MicroRNAs and Fetal Programming Hypothesis; 4. Evidence from Animal Experiments; 4.1. DNA Methylation and Animal Experiments
505	8		_a4.1.1. Maternal Nutrition4.1.2. Paternal Nutrition; 4.2. MicroRNAs and Animal Experiments; 4.2.1. Maternal Nutrition; 4.2.2. Paternal Nutrition; 5. Developmental Plasticity and Reversibility; Conclusion and Further Perspective; References; Chapter 2 EFFECTS OF OXIDATIVE STRESS ON EPIGENETIC MECHANISMS ; Abstract; Abbreviations; 1. Epigenetic Mechanisms; 1.1. DNA Methylation; 1.2. Histone Post-translational Modifications; 1.3. Micro RNAs and Epigenetic; 2. Oxidative Stress; 3. Interactions between Oxidative Stress and Epigenetic Mechanisms; 3.1. Oxidative Stress -- DNA Methylation
505	8		_a3.2. Oxidative Stress -- Histone Post-Translational Modifications3.3. Oxidative Stress -- miRNAs; Conclusion; References; Chapter 3 EPIGENETIC MODIFICATIONS AND THEIR POTENTIAL ROLE IN TUMORIGENESIS ; Abstract; Abbreviations; 1. Introduction; 2. The Dysregulation of Epigenetic Factors in Various Cancers; 2.1. The Deregulation of DNA Methylation in Cancer; 2.2. The Deregulation of Histone Lysine Methylation in Cancer; 2.3. The Deregulation of Histone Lysine Demethylases in Cancer; 3. Histone Lysine Acetylation in Cancer
505	8		_a3.1. The Deregulation of Histone Lysine Acetyltransferases in Tumor Proliferation and Metastasis3.2. The Deregulation of Histone Lysine Deacetylases (KDACs) in Cancer; 4. Histone Acetylation "Code" as a Diagnostic Marker for Cancer Progression; 5. Epigenetic Modifications in Oncogenes and Tumor Suppressor Genes; 6. Epigenetic Modifications in Cellular Signaling Pathways; 6.1. NF-(B Signaling Pathway; 6.2. STAT3 Signaling Cascade; 6.3. Wnt/(-Catenin Signaling Pathway; 7. Epigenetic Modification in Cancer Stem Cells
590			_aeBooks on EBSCOhost _bEBSCO eBook Subscription Academic Collection - Worldwide
650		0	_aEpigenetics. _0http://id.loc.gov/authorities/subjects/sh2011005133
650		0	_aGenetic regulation. _0http://id.loc.gov/authorities/subjects/sh85053870
650		2	_aEpigenomics.
650		7	_aSCIENCE _xLife Sciences _xBiochemistry. _2bisacsh
650		7	_aEpigenetics. _2fast _0(OCoLC)fst01893642
650		7	_aGenetic regulation. _2fast _0(OCoLC)fst00940086
655		4	_aElectronic books.
700	1		_aDincer, Yildiz, _eeditor.
776	0	8	_iPrint version: _tEpigenetics _dHauppauge, New York : Nova Science Publisher's, Inc., [2016] _z9781634844901 _w(DLC) 2015050167
830		0	_aGenetics--research and issues series. _0http://id.loc.gov/authorities/names/n2009183467
856	4	0	_uhttps://libproxy.firstcity.edu.my:8443/login?url=http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=1226247
938			_aYBP Library Services _bYANK _n12820878
938			_aEBSCOhost _bEBSC _n1226247
938			_aProQuest Ebook Central _bEBLB _nEBL4586617
994			_a92 _bMYFCU
999			_c49498 _d49498