Androgens : production, functions, and disorders /
Berkley F. Thompson and Devon J. Robinson, editors.
- 1 online resource.
- Endocrinology research and clinical developments .
- Endocrinology research and clinical developments. .
Includes bibliographical references and index.
ANDROGENS ; ANDROGENS ; Contents ; Preface ; Androgen Deprivation Therapy for Advanced Prostate Cancer on the Ground of Androgen Milieu in the Prostate; Abstract ; Abbreviations ; Introduction; Androgen Milieu in Blood ; Androgen Milieu in the Prostate; Prostate Cancer Aggressiveness and the Androgen Milieu in the Prostate and in Blood ; Intraprostatic Androgen Milieu during Androgen Deprivation Therapy ; Androgen Milieu in the Castration-Resistant Prostate Cancer ; Clinical-Translational Advances of Prostate Cancer ; Gonadotrophin-Releasing Hormone (GnRH) Antagonists: Degarelix. Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) InhibitorsAbiraterone Acetate (Zytiga, Johnson & Johnson) ; Orteronel (TAK-700) [(1S)-1-(6,7-Dimethoxy-2-Naphthyl)-1-(1H-Imidazol-4-Yl)-2-Methylpropan-1-Ol] ; TOK-001 (VN/124-1) [3 -Hydroxy-17-(1H-Benzimidazole-1-Yl)Androsta-5,16-Diene] ; 3.-Hydroxysteroid Dehydrogenase Inhibitors; Apoptone (HE3235) (17 -Ethynyl-5 -Androstan-3, 17 -Diol) ; Inhibitors Targeting Androgen Receptor; A New Androgen Receptor Antagonist, MDV3100 ; A New Androgen Receptor Antagonist, ARN-509. An Inhibitor of the Amino Terminal Domain (NTD) of the AR: EPI-001 The Prospects of the Androgen Deprivation Therapy on the Ground of Androgen Milieu in the Prostate ; Conclusion ; References ; Clinical Model of Androgen Deficiency -- Clinical Model of Androgen Deficiency -- Clinical Model of Androgen Deficiency -- Androgen Deprivation Therapy and Its Effect on Bone Metabolism, Metabolism and Cognitive Functions ; Introduction; Methods ; Androgen Deprivation Therapy (ADT) ; Testosterone: A Basal Overview of Biosynthesis, Metabolism and Its Action ; Androgens and Bone Metabolism. ADT and Its Side Effects Bone Loss and Osteoporosis ; Osteoporosis; Diagnosis of Osteoporosis ; ADT, PCa and Clinical Aspects of Bone Disease ; Treatment of ADT Induced Osteoporosis ; Androgens and Cognitive Functions ; Potential Mechanisms of Action ; Cognitive Functions and ADT; Androgen Deprivation Therapy and Changes in Body Composition ; ADT and Insulin Resistance ; Early Metabolic Changes ; Late Metabolic Changes ; ADT and Lipid Alterations ; ADT, Metabolic Syndrome and Cardiovascular Disease ; References; The Role of Testosterone in Male Erectile Dysfunction. 1. Erectile Dysfunction 2. Definitions; 2.1. Total Testosterone ; 2.2. Free Testosterone ; 2.3. Bio-Available/Bioactive Testosterone ; 3. Hypogonadism ; 3.1. Late Onset Hypogonadism ; 3.2. Hypogonadism Prevalence ; 4. Relationship between Testosterone and ED ; 5. Physiology of Erection ; 6. Influence of Testosterone on Penile Erection ; 6.1. NOS/cGMP Pathway ; 6.2. Source of NO ; 6.3. Phosphodiesterases (PDE); 7. Making the Diagnosis of Hypogonadism and Working up Erectile Dysfunction ; Patient History ; Physical Exam ; Laboratory Studies ; Specific Diagnostic Tests ; 7.1. Questionnaires.